Holmes caught a short pass from Jets quarterback Mark Sanchez and turned to make a move. However, he immediately dropped to the ground after turning awkwardly on his left foot. Upon falling, Holmes dropped the ball which was picked up by 49ers cornerback Carlos Rodgers who returned the fumble 51 yards for a score.
"That's really too bad," Sanchez said. "You'd love him to hang on to the ball, but at the same time, the guy's going down and he hurt himself, kind of assumed the play was over. Just another tough play."
Holmes is set to undergo an MRI today to determine the extent of his injury. After catching four passes for 29 yards on Sunday, the 28-year-old now has 20 receptions for 272 yards and one touchdown on the season.